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March 29, 2024
1 minute read
Important points:
- There was no significant difference in the 10-year eGFR slope between groups.
- Patients with baseline eGFR levels less than 80 mL/min/1.73 m2 Mean longitudinal eGFR was slightly higher.
In patients with type 2 diabetes whose kidney function was preserved through intensive lifestyle interventions, the eGFR slope did not change significantly over a 10-year period, researchers found.
“Obesity is a risk factor for type 2 diabetes and high blood pressure, two of the main causes. [chronic kidney disease] C.K.D.” linda marie U. Ravenburg, DO, MSCE; professors in the Division of Renal Electrolytes at the University of Pittsburgh School of Medicine and colleagues wrote. However, the researchers noted that “data regarding long-term renal outcomes after nonsurgical bariatric treatment are limited.”
A post hoc analysis evaluated 4,901 randomly selected adults aged 45 to 75 years with type 2 diabetes and a BMI of 25 kg/m or higher.2They were enrolled in the Action for Health in Diabetes (Look AHEAD) study. Researchers conducted a controlled trial from 2001 to 2015 to assess the 10-year effect of an intensive lifestyle intervention on kidney outcomes.
Patients were divided into two groups. Patients receiving intensive lifestyle interventions and patients receiving diabetes support and education as part of their usual care. Overall, the mean baseline eGFR was 89 mL/min/1.73 m.2 83% of patients had normal urinary albumin-to-creatinine ratio (UACR). The primary outcome was her eGFR slope, followed by mean eGFR and UACR.
Results showed no significant difference in 10-year eGFR slope between groups. Patients with baseline eGFR levels below her 80 had a slightly higher long-term average eGFR with the lifestyle intervention compared to usual care. Findings showed that her baseline eGFR level did not influence the effect of the intervention on her eGFR slope or mean. The slope and average UACR also did not change significantly.
“Intensive lifestyle interventions are an individualized and effective approach to weight loss,” wrote Ravenberg et al. “However, when studying the effects of weight loss interventions on kidney function, more rigorous measurements of kidney function are needed to overcome the effects of changes in diet and body composition associated with weight loss approaches.”
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Disclosure: Dr. Ravenberg reports being a co-investigator on an investigator-initiated observational study sponsored by Pfizer.
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